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ZXX2-77

An inhibitor of COX-1
Catalog #: B2937
SKU-Size Size Price Qty
B2937-5 5 mg
$65.00
B2937-25 25 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name 4-Amino-N-(4-chlorophenyl)-N-methyl-benzenesulfonamide; N-(4-Chlorophenyl)-N-methyl-4-aminobenzenesulfonamide; 4-Amino-4'-chloro-N-methylbenzenesulfonanilide; COX-1 Inhibitor II
Appearance Solid
CAS # 304913-22-2
Molecular Formula C₁₃H₁₃ClN₂O₂S
Molecular Weight 296.77
Purity 97%
Solubility Soluble in DMSO
SMILES CN(C1=CC=C(C=C1)Cl)S(=O)(=O)C2=CC=C(C=C2)N
InChi InChI=1S/C13H13ClN2O2S/c1-16(12-6-2-10(14)3-7-12)19(17,18)13-8-4-11(15)5-9-13/h2-9H,15H2,1H3
InChi Key AFQPTMJHMKDDIB-UHFFFAOYSA-N
PubChem CID 16126699
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

ZXX2-77 is a benzenesulfonanilide derivative that inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. It shows more potent analgesic activity than aspirin at 30 mg/kg by po. It can be used as a lead compound to develop better COX-1 inhibitors as analgesic agents without gastric disturbance.


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