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A potent and specific phosphoinositide 3-kinase (PI3K) inhibitor
Catalog #: 1597

In stock

SKU-Size Size Price Qty
1597-25 25 mg
1597-100 100 mg

Product Details

Alternate Name 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
Appearance White solid
CAS # 475110-96-4
Molecular Formula C₁₉H₂₁F₂N₇O₂S
Molecular Weight 417.41
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
InChi InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
PubChem CID 11647372
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in vitro and as in vivo. Displays strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice.

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