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Zotarolimus

An immunosuppressant
Catalog #: 9530
SKU-Size Size Price Qty
9530-1 1 mg
$125.00
9530-5 5 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid; L 758298;
Appearance White to off-white solid
CAS # 221877-54-9
Molecular Formula C₅₂H₇₉N₅O₁₂
Molecular Weight 966.21
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)N5C=NN=N5)C)C)O)OC)C)C)C)OC
InChi C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]@H]([[email protected]@H](C4)OC)N5C=NN=N5)C)/C)O)OC)C)C)/C)OC
InChi Key CGTADGCBEXYWNE-JUKNQOCSSA-N
PubChem CID 9876378
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the immunophilin FKBP12 and comparable potency for inhibiting in vitro proliferation of both human and rat T cells. In vitro, zotarolimus inhibited FKBP-12 binding (IC50 = 2.8 nM) and potently blocked smooth muscle cell (IC₅₀ = 2.9 nM) and endothelial cell (IC₅₀ = 2.6 nM) proliferation.


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