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ZM306416

An inhibitor of VEGF(KDR and Flt) receptor tyrosine kinase
Catalog #: B2915
SKU-Size Size Price Qty
B2915-5 5 mg
$75.00
B2915-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine; 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline; CB-676475
Appearance A crystalline solid
CAS # 690206-97-4
Molecular Formula C₁₆H₁₃ClFN₃O₂
Molecular Weight 333.74
Purity ≥98%
Solubility ~20 mg/ml in Ethanol
~50 mg/ml in DMSO and DMF
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC
InChi InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
InChi Key YHUIUSRCUKUUQA-UHFFFAOYSA-N
PubChem CID 5329006
MDL Number MFCD02683969
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀ value below 10 nM in a luminescence ADP production kinase assay.


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