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ZM 447439

A potent Aurora B kinase inhibitor
Catalog #: 2018
SKU-Size Size Price Qty
2018-1 1 mg
$80.00
2018-5 5 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Appearance Orange solid
CAS # 331771-20-1
Molecular Formula C₂₉H₃₁N₅O₄
Molecular Weight 513.59
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
InChi InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChi Key OGNYUTNQZVRGMN-UHFFFAOYSA-N
PubChem CID 9914412
MDL Number MFCD08703125
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 μM).


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