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ZM 336372

A c-Raf kinase inhibitor
Catalog #: 1789
SKU-Size Size Price Qty
1789-1 1 mg
$105.00
1789-5 5 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
Appearance White to off-white solid
CAS # 208260-29-1
Molecular Formula C₂₃H₂₃N₃O₃
Molecular Weight 389.45
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O
InChi InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChi Key PYEFPDQFAZNXLI-UHFFFAOYSA-N
PubChem CID 5730
MDL Number MFCD02683971
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC₅₀= 2 μM).


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