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Product Details
| Alternate Name | 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride |
|---|---|
| Appearance | White solid |
| CAS # | 723249-01-2 (Free base) |
| Molecular Formula | C₁₃H₁₃BrN₂OS.HCl |
| Molecular Weight | 361.69 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) |
| SMILES | CC1=CC(=C(C=C1)OCCSC2=NC=CC=N2)Br.Cl |
| InChi | InChI=1S/C13H13BrN2OS.ClH/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13;/h2-6,9H,7-8H2,1H3;1H |
| InChi Key | MMQCYIMDROWWFE-UHFFFAOYSA-N |
| PubChem CID | 91654626 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC₅₀s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively. Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.
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