ZLN024 hydrochloride

An allosteric AMPK activator
Catalog #: B2034 | abID:

Product Details

Alternate Name 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Appearance White solid
CAS # 723249-01-2 (Free base)
Molecular Formula C₁₃H₁₃BrN₂OS.HCl
Molecular Weight 361.69
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
InChi InChI=1S/C13H13BrN2OS.ClH/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13;/h2-6,9H,7-8H2,1H3;1H
PubChem CID 91654626
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC₅₀s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively. Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.

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