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VX-222

A potent, non-nucleoside inhibitor of HCV polymerase
Catalog #: B2207

In stock

SKU-Size Size Price Qty
B2207-5 5 mg
$145.00
B2207-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid; Lomibuvir; VCH-222
Appearance Crystalline solid
CAS # 1026785-59-0
Molecular Formula C₂₅H₃₅NO₄S
Molecular Weight 445.6
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
InChi InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)
InChi Key WPMJNLCLKAKMLA-UHFFFAOYSA-N
PubChem CID 24798764
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VX-222 is a potent, non-nucleoside inhibitor of HCV polymerase (IC₅₀ = 0.94-1.2 μM). It is 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.


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