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Zanubrutinib

A potent, selective and orally available Btk inhibitor
Catalog #: B2512
SKU-Size Size Price Qty
B2512-1 1 mg
$135.00
B2512-5 5 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name (7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; BGB-3111; (S)-Zanubrutinib; BGB3111
Appearance White to off-white solid
CAS # 1691249-45-2
Molecular Formula C₂₇H₂₉N₅O₃
Molecular Weight 471.56
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES C=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N
InChi InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18, 22,29H,1,12-17H2,(H2,28,34)
InChi Key RNOAOAWBMHREKO-UHFFFAOYSA-N
PubChem CID 135905454
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib. BGB-3111 selectively binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.


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