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Z-YVAD-FMK

based on 10 citations in multiple journalsZ-YVAD-FMK104.2 4
A caspase-1 inhibitor
Catalog #: 1141
SKU-Size Size Price Qty
1141-1 1 mg
$265.00
1141-5 5 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Z-YVAD-FMK, Z-YVAD-fluoromethylketone, Caspase-1 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₁H₃₉FN₄O₉
Molecular Weight 630.7
Purity Single spot by TLC
Solubility DMSO (20 mM)
SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2
InChi InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1
InChi Key MVPQJUFFTWWKBT-UYDLRUHXSA-N
PubChem CID 16760349
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Karunakaran, Denuja et al. (2016) Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis Sci Adv. 2016 Jul 22;2(7):e1600224
Han et al., Caspase-Mediated Apoptosis in the Cochleae Contributes to the Early Onset of Hearing Loss in A/J Mice.ASN Neuro, Feb 2015; 7: 1759091415573985.
Robinson et al., Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization. J. Biol. Chem., Nov 2014; 289: 31983 - 31994.
Wang et al., Farnesol induces apoptosis-like cell death in the pathogenic fungusAspergillus flavus. Mycologia, Sep 2014; 106: 881 - 888.
Kim et al., Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms. Invest. Ophthalmol. Vis. Sci., Aug 2014; 55: 4747 - 4758.
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