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Z-VEID-FMK

based on 2 citations in multiple journalsZ-VEID-FMK24.1 4
A caspase-6 inhibitor
Catalog #: 1146
SKU-Size Size Price Qty
1146-1 1 mg
$235.00
1146-5 5 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Z-VEID-FMK, Z-VEID-fluoromethylketone, Caspase-6 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Val-E(OMe)-Ile-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₁H₄₅FN₄O₁₀
Molecular Weight 652.9
Purity Single spot by TLC
Solubility DMSO (20 mM)
SMILES CCC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C31H45FN4O10/c1-7-19(4)27(30(42)34-22(23(37)16-32)15-25(39)45-6)35-28(40)21(13-14-24(38)44-5)33-29(41)26(18(2)3)36-31(43)46-17-20-11-9-8-10-12-20/h8-12,18-19,21-22,26-27H,7,13-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,40)(H,36,43)
InChi Key YPIHFMWAHMPACV-UHFFFAOYSA-N
PubChem CID 44135214
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Pianu et al., The Aβ1-42 peptide regulates microtubule stability independently of tau. J. Cell Sci., Mar 2014; 127: 1117 - 1127.
Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
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