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based on 6 citations in multiple journalsZ-VDVAD-FMK64.1 4
A caspase-2 inhibitor
Catalog #: 1142
SKU-Size Size Price Qty
1142-1 1 mg
1142-5 5 mg
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Product Details

Alternate Name Z-VDVAD-FMK, Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₂H₄₆FN₅O₁₁
Molecular Weight 695.7
Purity Single spot by TLC
Solubility DMSO (20 mM)
InChi InChI=1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1
PubChem CID 25108684
MDL Number MFCD03452881
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

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