A pan-caspase inhibitor

Z-VAD-FMK is available from Abcam as ab120487.
Catalog #: 1140 | abID:

Product Details

Alternate Name Z-VAD-FMK, Z-VAD-fluoromethylketone, Caspase-Family Inhibitor (fluoromethylketone)
Peptide Sequence Z-Val-Ala-Asp(OMe)-FMK
Appearance Lyophilized solid
CAS # 187389-52-2
Molecular Formula C₂₂H₃₀N₃O₇F
Molecular Weight 467.5
Purity Single spot by TLC
Solubility DMSO (20 mM)
InChi InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)
PubChem CID 5737
MDL Number MFCD01074990
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

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Jia, Yali et al. (2017) Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway, Ultrasonics. 2017 Jan;73:154-161.
Karunakaran, Denuja et al. (2016) Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis Sci Adv. 2016 Jul 22;2(7):e1600224
Han et al., Caspase-Mediated Apoptosis in the Cochleae Contributes to the Early Onset of Hearing Loss in A/J Mice.ASN Neuro, Feb 2015; 7: 1759091415573985.
Robinson et al., Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization. J. Biol. Chem., Nov 2014; 289: 31983 - 31994.
Wang et al., Farnesol induces apoptosis-like cell death in the pathogenic fungusAspergillus flavus. Mycologia, Sep 2014; 106: 881 - 888.
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