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Product Details
| Alternate Name | Z-LEVD-FMK, Z-LEVD-fluoromethylketone, Caspase-4 Inhibitor (fluoromethylketone) |
|---|---|
| Peptide Sequence | Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK |
| Appearance | Lyophilized solid |
| Molecular Formula | C₃₁H₄₅FN₄O₁₀ |
| Molecular Weight | 652.7 |
| Purity | Single spot by TLC |
| Solubility | DMSO (20 mM) |
| SMILES | CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40) |
| InChi Key | WGJLXPZGHLANRB-UHFFFAOYSA-N |
| PubChem CID | 44135220 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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Burm et al., Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases. J. Neurosci., Jan 2015; 35: 678 - 687.
Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
Binet, F. et. al. Interaction between arsenic trioxide (ATO) and human neutrophils. Human and Experimental Toxicology, May 2011; 30: 416 - 424.
Rosati, E. et al. Novel Targets for Endoplasmic Reticulum Stress-Induced Apoptosis in B-CLL. Blood, 2010; 116: 2713-2723.
Wei, P. et al. The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy. Clin. Cancer Res.., 2010; 16: 3923-3932.
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