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Product Details
| Alternate Name | Z-LEHD-FMK, Z-LEHD-fluoromethylketone, Caspase-9 Inhibitor (fluoromethylketone) |
|---|---|
| Peptide Sequence | Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK |
| Appearance | Lyophilized solid |
| Molecular Formula | C₃₂H₄₃FN₆O₁₀ |
| Molecular Weight | 690.71 |
| Purity | Single spot by TLC |
| Solubility | DMSO (20 mM) |
| SMILES | CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2 |
| InChi | InChI=1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46) |
| InChi Key | YXRKBEPGVHOXSV-UHFFFAOYSA-N |
| PubChem CID | 44135217 |
| MDL Number | MFCD01862609 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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Kim et al., Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms. Invest. Ophthalmol. Vis. Sci., Aug 2014; 55: 4747 - 4758.
Pianu et al., The Aβ1-42 peptide regulates microtubule stability independently of tau. J. Cell Sci., Mar 2014; 127: 1117 - 1127.
Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
Du, Z.J. et. al. Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death. Invest. Ophthalmol. Vis. Sci., Feb 2011; 52: 987 - 993.
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