A caspase-8 inhibitor

1148 is available from Abcam as ab141382.
Catalog #: 1148 | abID: ab141382

Product Details

abID ab141382
Alternate Name Z-IETD-FMK, Z-IETD-fluoromethylketone, Caspase-8 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₀H₄₃FN₄O₁₁
Molecular Weight 654.7
Purity Single spot by TLC
Solubility DMSO (20 mM)
InChi InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)
PubChem CID 44135212
MDL Number MFCD01861686
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)

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