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Z-IETD-FMK

based on 8 citations in multiple journalsZ-IETD-FMK84.1 4
A caspase-8 inhibitor
Catalog #: 1148
SKU-Size Size Price Qty
1148-1 1 mg
$255.00
1148-5 5 mg
$675.00
More Sizes Get Quote

Product Details

Alternate Name Z-IETD-FMK, Z-IETD-fluoromethylketone, Caspase-8 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₀H₄₃FN₄O₁₁
Molecular Weight 654.7
Purity Single spot by TLC
Solubility DMSO (20 mM)
SMILES CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)
InChi Key PHLCQASLWHYEMX-UHFFFAOYSA-N
PubChem CID 44135212
MDL Number MFCD01861686
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)


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Kim et al., Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms. Invest. Ophthalmol. Vis. Sci., Aug 2014; 55: 4747 - 4758.
Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
Hara, K. et. al. Recovery of Anoikis in Src-Transformed Cells and Human Breast Carcinoma Cells by Restoration of the SIRP{alpha}1/SHP-2 Signaling System. Cancer Res., Feb 2011; 71: 1229 - 1234.
Du, Z.J. et. al. Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death. Invest. Ophthalmol. Vis. Sci., Feb 2011; 52: 987 - 993.
Abdul-Ghani, M. et. al. Wnt11 Promotes Cardiomyocyte Development by Caspase-Mediated Suppression of Canonical Wnt Signals. Mol. Cell. Biol., Jan 2011; 31: 163 - 178.
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