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Product Details
| Alternate Name | Z-IETD-FMK, Z-IETD-fluoromethylketone, Caspase-8 Inhibitor (fluoromethylketone) |
|---|---|
| Peptide Sequence | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK |
| Appearance | Lyophilized solid |
| Molecular Formula | C₃₀H₄₃FN₄O₁₁ |
| Molecular Weight | 654.7 |
| Purity | Single spot by TLC |
| Solubility | DMSO (20 mM) |
| SMILES | CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43) |
| InChi Key | PHLCQASLWHYEMX-UHFFFAOYSA-N |
| PubChem CID | 44135212 |
| MDL Number | MFCD01861686 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)
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Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
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Du, Z.J. et. al. Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death. Invest. Ophthalmol. Vis. Sci., Feb 2011; 52: 987 - 993.
Abdul-Ghani, M. et. al. Wnt11 Promotes Cardiomyocyte Development by Caspase-Mediated Suppression of Canonical Wnt Signals. Mol. Cell. Biol., Jan 2011; 31: 163 - 178.
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