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A selective farnesoid X receptor (FXR) modulator
Catalog #: B2773
SKU-Size Size Price Qty
B2773-5 5 mg
B2773-25 25 mg
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Product Details

Alternate Name 4,17(20)-trans-Pregnadiene-3,16-dione; (17Z)-Pregna-4,17(20)-diene-3,16-dione
Peptide Sequence N/A
Appearance Off-white solid
CAS # 39025-23-5
Molecular Formula C₂₁H₂₈O₂
Molecular Weight 312.45
Purity ≥98%
Solubility >5 mg/ml DMSO
InChi InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
PubChem CID 6450278
MDL Number MFCD01310757
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


(Z)-Guggulsterone is a synthetic form of the guggul tree plant steroid that displays an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).

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