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based on 1 citations in multiple journalsZ-FA-FMK14.1 4
Anirreversible inhibitor of cathepsins B, L, and S
Catalog #: 1986
SKU-Size Size Price Qty
1986-1 1 mg
1986-5 5 mg
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Product Details

Alternate Name Benzyloxycarbonyl-Phe-Ala-Fluoromethylketone; Z-Phe-Ala fluoromethyl ketone; Z-Phe-Ala-FMK
Peptide Sequence Z-FA-FMK
Appearance White to off-white solid
CAS # 105637-38-5
Molecular Formula C₂₁H₂₃N₂O₄F
Molecular Weight 386.42
Purity ≥95% by HPLC
Solubility DMSO (20 mM)
InChi InChI=1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)
PubChem CID 122019
MDL Number MFCD00883668
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A useful negative control for FMK-labeled caspase inhibitors. Also, an irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain.

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Xia et al., Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells. J. Biol. Chem., Jul 2013; 288: 19321 - 19329.
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