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Z-DEVD-FMK

based on 15 citations in multiple journalsZ-DEVD-FMK154.6 5
A caspase-3 inhibitor
Catalog #: 1143
SKU-Size Size Price Qty
1143-1 1 mg
$245.00
1143-5 5 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name Z-DEVD-FMK, Z-DEVD-fluoromethylketone, Caspase-3 inhibitor (fluoromethylketone)
Peptide Sequence Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₃₀H₄₁FN₄O₁₂
Molecular Weight 668.7
Purity Single spot by TLC
Solubility DMSO (20 mM)
SMILES CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChi Key GBJVAVGBSGRRKN-JYEBCORGSA-N
PubChem CID 16760394
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Dick et al., Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. PNAS, Sep 2015; 112: E5246 - E5252.
Kim et al., Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms. Invest. Ophthalmol. Vis. Sci., Aug 2014; 55: 4747 - 4758.
Moon et al., CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol, Aug 2014; 307: L326 - L337.
Pianu et al., The Aβ1-42 peptide regulates microtubule stability independently of tau. J. Cell Sci., Mar 2014; 127: 1117 - 1127.
Heinhuis, B. et al., Interleukin 32 (IL-32) Contains a Typical α-Helix Bundle Structure That Resembles Focal Adhesion Targeting Region of Focal Adhesion Kinase-1, J. Biol. Chem., Feb 2012; 287: 5733 - 5743.
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