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Z-ATAD-FMK

based on 7 citations in multiple journalsZ-ATAD-FMK74.1 4
A caspase-12 inhibitor
Catalog #: 1152
SKU-Size Size Price Qty
1152-1 1 mg
$275.00
1152-5 5 mg
$795.00
More Sizes Get Quote

Product Details

Alternate Name Z-ATAD-FMK, Z-ATAD-fluoromethylketone, Caspase-12 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Ala-Thr-Ala-Asp(OMe)-FMK
Appearance Lyophilized solid
Molecular Formula C₂₄H₃₃FN₄O₉
Molecular Weight 540.54
Purity Single spot by TLC
Solubility DMSO (20 mM)
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Eric A. Ariazi, et. al. Inaugural Article: Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS, Nov 2011; 108: 18879 - 18886.
Dolai, S. et. al. Endoplasmic Reticulum Stress-induced Apoptosis in Leishmania through Ca2+-dependent and Caspase-independent Mechanism. J. Biol. Chem., Apr 2011; 286: 13638 - 13646.
Suzuki, H. et. al. TDP-43-induced Death Is Associated with Altered Regulation of BIM and Bcl-xL and Attenuated by Caspase-mediated TDP-43 Cleavage. J. Biol. Chem., Apr 2011; 286: 13171 - 13183.
Auner, H.W. et. al. The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress. Blood, Nov 2010; 116: 3445 - 3455.
Fu HY et al (2008) Cardiovasc Res 79: 600-610.
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