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Product Details
| Alternate Name | Z-A-E(OMe)-V-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; FK033 |
|---|---|
| Peptide Sequence | Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK |
| Appearance | Lyophilized solid |
| CAS # | 1135688-47-9 |
| Molecular Formula | C₂₈H₃₉FN₄O₁₀ |
| Molecular Weight | 610.63 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (~ 10 mg/ml) |
| SMILES | CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1 |
| InChi Key | CHZRBQFKZDGMTP-CDSYHYPYSA-N |
| PubChem CID | 25108694 |
| MDL Number | MFCD03453601 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Z-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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