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(Z)-4-Hydroxytamoxifen

A potent estrogen receptor antagonist and Cas9 activator
Catalog #: B1114
SKU-Size Size Price Qty
B1114-5 5 mg
$225.00
B1114-25 25 mg
$895.00
More Sizes Get Quote

Product Details

Alternate Name 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; 4-OH-TAM
Appearance White solid
CAS # 68047-06-3
Molecular Formula C₂₆H₂₉NO₂
Molecular Weight 387.51
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml) or H2O (>10 mg/ml)
SMILES CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
InChi InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChi Key TXUZVZSFRXZGTL-QPLCGJKRSA-N
PubChem CID 449459
MDL Number MFCD00278780
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen (Cat. No. 1551); acts as a potent estrogen receptor antagonist. Displays more potency than the parent compound. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing.


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