Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

YW3-56 (hydrochloride)

An inhibitor of PAD2 and PAD4
Catalog #: B2858
SKU-Size Size Price Qty
B2858-500 500 µg
$175.00
B2858-1000 1000 µg
$675.00
More Sizes Get Quote

Product Details

Alternate Name N-[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]-6-(dimethylamino)-2-naphthalenecarboxamide, monohydrochloride
Formulation A solution in methanol
Molecular Formula C₂₇H₃₂ClN₅O₂.HCl
Molecular Weight 530.49
Purity ≥80%
SMILES CN(C)C1=CC=C2C(C=CC(C(N[[email protected]@H](CCCNC(CCl)=N)C(NCC3=CC=CC=C3)=O)=O)=C2)=C1.Cl
InChi InChI=1S/C27H32ClN5O2.ClH/c1-33(2)23-13-12-20-15-22(11-10-21(20)16-23)26(34)32-24(9-6-14-30-25(29)17-28)27(35) 31-18-19-7-4-3-5-8-19;/h3-5,7-8,10-13,15-16,24H,6,9,14,17-18H2,1-2H3,(H2,29,30)(H,31,35)(H,32,34);1H/t24-;/m0./s1
InChi Key DBGNVJZDXMWWQR-JIDHJSLPSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 which convert protein arginine residues to citrulline. The IC₅₀ for inhibition of PAD4 and PAD2 is about 1–2 μM and 0.5–1 μM respectively. YW3-56 inhibits the growth of osteosarcoma U2OS cells with an IC₅₀ of 2.5 μM. YW3-56 induces p53 target genes SESN2 and DDIT4 which repress mTORC1 kinase activity. It perturbs autophagy and inhibits the growth of triple-negative breast cancer xenograft tumors in mice.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.