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A PIKfyve inhibitor
Catalog #: 2045
SKU-Size Size Price Qty
2045-1 1 mg
2045-5 5 mg
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Product Details

Alternate Name 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide
Appearance White to off-white solid
CAS # 371942-69-7
Molecular Formula C₂₅H₂₁N₇O₃
Molecular Weight 467.49
Purity ≥98% by NMR
Solubility DMSO or EtOH
InChi InChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33)
PubChem CID 9956222
MDL Number MFCD16038303
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC50 = 33 nM). It inhibits p110α at higher concentration (IC50 = 3 µM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA.YM-201636 also blocks retroviral exit by budding from cells.

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