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YM-90709 is a novel, selective inhibitor of interleukin-5 (IL-5).
Catalog #: B1074

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SKU-Size Size Price Qty
B1074-10 10 mg
B1074-50 50 mg
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Product Details

Alternate Name 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Appearance Yellow solid
CAS # 163769-88-8
Molecular Formula C₂₂H₂₁N₃O₂
Molecular Weight 359.43
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
PubChem CID 1103147
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC₅₀ values of 1.0 and 0.57 µM, respectively. In functional assays, YM-90709 inhibits IL-5-prolonged eosinophil survival with an IC₅₀ value of 0.45 µM and does not affect the GM-CSF-prolonged eosinophil survival.

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