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YM-254890

Gα-protein inhibitor
Catalog #: B3393
$115.00

Product Details

Cat # +Size B3393-100
Size 100 mg
Alternate Name N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-L-threonine(7→1)-lactone
Appearance Clear lyophilized film
CAS # 568580-02-9
Molecular Formula C₄₆H₆₉N₇O₁₅
Molecular Weight 960.09
Purity ≥95% by HPLC
Solubility >8 mg/ml DMSO
SMILES [H][[email protected]]1(N(C([[email protected]]([[email protected]@H](C(C)C)OC([[email protected]]([[email protected]@H](C(C)C)O)NC(C)=O)=O)NC([[email protected]@H](N(C([[email protected]@H](NC(C(N(C([[email protected]](OC([[email protected]]([[email protected]](OC1=O)C)NC(C)=O)=O)CC2=CC=CC=C2)=O)C)=C)=O)C)=O)C)C)=O)=O)C)[[email protected]](OC)C
InChi InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1
InChi Key QVYLWCAYZGFGNF-WBWCVGBTSA-N
PubChem CID 9919454
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

YM-254890 is a cyclic depsipeptide that acts as a Gα-protein inhibitor. It potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol-induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP-induced Ca2+ increase in platelets, in vitro (IC50 = 2 μM).


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