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A salt-inducible kinase (SIK) inhibitor
Catalog #: B3387
SKU-Size Size Price Qty
B3387-5 5 mg
B3387-25 25 mg
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Product Details

Alternate Name 3-(2-chloro-6-methylphenyl)-7-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-1-(5-methoxypyridin-2-yl)-4H-pyrimido[4,5-d]pyrimidin-2-one
Appearance Solid
CAS # 1936529-65-5
Molecular Formula C₃₂H₃₄ClN₇O₃
Molecular Weight 600.11
Purity ≥98%
Solubility >50 mg/ml DMSO
InChi InChI=1S/C32H34ClN7O3/c1-20-6-5-7-25(33)29(20)39-19-23-17-35-31(37-30(23)40(32(39)41)28-11-9-24(42-3)18-34-28)36-26-10-8-22(16-27(26)43-4)21-12-14-38(2)15-13-21/h5-11,16-18,21H,12-15,19H2,1-4H3,(H,35,36,37)
PubChem CID 121596782
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


YKL-05-099 is an inhibitor of the salt-inducible kinase (SIK1 and SIK3; IC50s: 10 and 30 nM, respectively). It displays less potency towards SIK2 (IC50 = 40 nM). YKL-05-099 Suppresses acute myeloid leukemia progression in vivo.

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