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A sirtuin 1 (SIRT1) activator
Catalog #: B2762
SKU-Size Size Price Qty
B2762-5 5 mg
B2762-25 25 mg
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Product Details

Alternate Name B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Peptide Sequence N/A
Appearance Yellow solid
CAS # 1215281-19-8
Molecular Formula C₁₉H₂₁BO₇
Molecular Weight 372.18
Purity ≥98% by HPLC
Solubility >30 mg/ml Ethanol; >30 mg/ml DMSO
InChi InChI=1S/C19H21BO7/c1-24-16-8-6-12(9-14(16)20(22)23)5-7-15(21)13-10-17(25-2)19(27-4)18(11-13)26-3/h5-11,22-23H,1-4H3/b7-5+
PubChem CID 24881094
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


YK-3-237 is a sirtuin 1(SIRT1) activator. It activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = <0.01-20.9 μM).

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