Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

YC-1

A soluble guanylyl cyclase (sGC) activator
Catalog #: 2061
SKU-Size Size Price Qty
2061-5 5 mg
$90.00
2061-25 25 mg
$345.00
More Sizes Get Quote

Product Details

Alternate Name 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; Lificiguat
Appearance White to pale yellow solid
CAS # 170632-47-0
Molecular Formula C₁₉H₁₆N₂O₂
Molecular Weight 304.34
Purity ≥98% by NMR
Solubility DMSO (100 mM) or EtOH (50 mM)
SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
InChi InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChi Key OQQVFCKUDYMWGV-UHFFFAOYSA-N
PubChem CID 5712
MDL Number MFCD06407798
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.