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Product Details
| Alternate Name | 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; Lificiguat |
|---|---|
| Appearance | White to pale yellow solid |
| CAS # | 170632-47-0 |
| Molecular Formula | C₁₉H₁₆N₂O₂ |
| Molecular Weight | 304.34 |
| Purity | ≥98% by NMR |
| Solubility | DMSO (100 mM) or EtOH (50 mM) |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO |
| InChi | InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2 |
| InChi Key | OQQVFCKUDYMWGV-UHFFFAOYSA-N |
| PubChem CID | 5712 |
| MDL Number | MFCD06407798 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.
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