A soluble guanylyl cyclase (sGC) activator
Catalog #: 2061 | abID:

Product Details

Alternate Name 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; Lificiguat
Appearance White to pale yellow solid
CAS # 170632-47-0
Molecular Formula C₁₉H₁₆N₂O₂
Molecular Weight 304.34
Purity ≥98% by NMR
Solubility DMSO (100 mM) or EtOH (50 mM)
InChi InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
PubChem CID 5712
MDL Number MFCD06407798
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.

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