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Y15

A selective focal adhesion kinase (FAK) inhibitor having antiproliferative activity
Catalog #: B1252
SKU-Size Size Price Qty
B1252-10 10 mg
$85.00
B1252-50 50 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 1,2,4,5-benzenetetramine, tetrahydrochloride
Appearance Light Yellow Solid
CAS # 4506-66-5
Molecular Formula C₆H₁₀N₄•4HCl
Molecular Weight 284.01
Purity ≥95%
Solubility DMSO (>20 mg/ml) or (H₂O (>15 mg/ml)
SMILES C1=C(C(=CC(=C1N)N)N)N.Cl.Cl.Cl.Cl
InChi InChI=1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
InChi Key BZDGCIJWPWHAOF-UHFFFAOYSA-N
PubChem CID 78260
MDL Number MFCD00012970
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Y15 is a selective focal adhesion kinase (FAK) inhibitor preventing FAK autophosphorylation at IC₅₀ of 1 μM. It does not have any significant activity against a range of other kinases like EGFR, PDGFR, and IG-RI. Y15 has shown to promote cell detachment inhibiting cell adhesion in in vitro experiments, shows antiproliferative activity in variety of tumor cell lines. In vivo it has shown to inhibit the proliferation in breast cancer cells.


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