Product Details
| Alternate Name | 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 2375193-43-2 |
| Molecular Formula | C₂₃H₂₄ClF₂NO₃ |
| Molecular Weight | 435.9 |
| Purity | ≥98% |
| Solubility | >5 mg/ml in DMSO |
| SMILES | C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl |
| InChi | InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H |
| InChi Key | OKFZPRHMUQRCLJ-UHFFFAOYSA-N |
| PubChem CID | 135397144 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.
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