A specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor
Catalog #: B2381 | abID:

Product Details

Alternate Name 2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride
Appearance Crystalline solid
CAS # 2375193-43-2
Molecular Formula C₂₃H₂₄ClF₂NO₃
Molecular Weight 435.9
Purity ≥98%
Solubility >5 mg/ml in DMSO
InChi InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H
PubChem CID 135397144
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is restricted to MM containing bones and blocks the effects and upregulation of tumor necrosis factor alpha (TNFα), an osteoblast (OB) differentiation inhibitor that is increased in the MM bone marrow microenvironment and utilizes signaling complexes formed on p62-ZZ, in BMSC.

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