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XMD8-87

A potent Ack1/TNK2 inhibitor
Catalog #: B2647
SKU-Size Size Price Qty
B2647-1 1 mg
$75.00
B2647-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Appearance Off-white solid
CAS # 1234480-46-6
Molecular Formula C₂₄H₂₇N₇O₂
Molecular Weight 445.5
Purity ≥98% by HPLC
Solubility >20 mg/ml DMSO
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4)C)OC
InChi InChI=1S/C24H27N7O2/c1-29-10-12-31(13-11-29)16-8-9-18(21(14-16)33-3)27-24-25-15-19-22(28-24)30(2)20-7-5-4-6-17(20)23(32)26-19/h4-9,14-15H,10-13H2,1-3H3,(H,26,32)(H,25,27,28)
InChi Key LGLHCXISMKHLIK-UHFFFAOYSA-N
PubChem CID 53322923
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of TNK2 truncation mutations found in solid tumor types.


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