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XL765

A dual PI3K/mTOR inhibitor
Catalog #: 2551
SKU-Size Size Price Qty
2551-5 5 mg
$145.00
2551-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 2-Amino-8-ethyl-4-methyl-6-(lH-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one; SAR245409
Appearance White solid
CAS # 934493-76-2
Molecular Formula C₁₃H₁₄N₆O
Molecular Weight 270.29
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCN1C2=NC(=NC(=C2C=C(C1=O)C3=CC=NN3)C)N
InChi InChI=1S/C13H14N6O/c1-3-19-11-8(7(2)16-13(14)17-11)6-9(12(19)20)10-4-5-15-18-10/h4-6H,3H2,1-2H3,(H,15,18)(H2,14,16,17)
InChi Key RGHYDLZMTYDBDT-UHFFFAOYSA-N
PubChem CID 16123056
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.


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