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An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor
Catalog #: B2204

In stock

SKU-Size Size Price Qty
B2204-1 1 mg
B2204-5 5 mg
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Product Details

Alternate Name N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine; Tesevatinib; EXEL-7647; KD-019
Appearance Crystalline solid
CAS # 781613-23-8
Molecular Formula C₂₄H₂₅Cl₂FN₄O₂
Molecular Weight 491.38
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+
PubChem CID 10458325
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


XL-647 is an orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. It binds to and inhibits several receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4).

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