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XAV939

A Tankyrase (TNKS) inhibitor
Catalog #: 1727
$105.00

Product Details

Cat # +Size 1727-1
Size 1 mg
Alternate Name 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Appearance White solid
CAS # 284028-89-3
Molecular Formula C₁₄H₁₁F₃N₂OS
Molecular Weight 312.31
Purity ≥98% by HPLC
Solubility DMSO (50 mM)
SMILES C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
InChi InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChi Key KLGQSVMIPOVQAX-UHFFFAOYSA-N
PubChem CID 2726824
MDL Number MFCD16879017
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.


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