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Xanthohumol

Valosin-containing protein (VCP) inhibitor
Catalog #: 2258
SKU-Size Size Price Qty
2258-5 5 mg
$85.00
2258-25 25 mg
$340.00
More Sizes Get Quote

Product Details

Alternate Name (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)- 2-propen-1-one
Peptide Sequence No
Appearance Yellow solid
CAS # 6754-58-1
Molecular Formula C₂₁H₂₂O₅
Molecular Weight 354.4
Purity ≥98% by TLC
Solubility DMSO (~35 mg/ml) or EtOH (~35 mg/ml)
SMILES CC(=CCC1=C(C=C(C(=C1O)C(=O)C=CC2=CC=C(C=C2)O)OC)O)C
InChi InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChi Key ORXQGKIUCDPEAJ-YRNVUSSQSA-N
PubChem CID 639665
MDL Number MFCD00210576
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). Impairs prostate cancer cell growth and proliferation.


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