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WZ-8040

A potent EGFR inhibitor
Catalog #: B2205

In stock

SKU-Size Size Price Qty
B2205-5 5 mg
$145.00
B2205-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Appearance Crystalline solid
CAS # 1214265-57-2
Molecular Formula C₂₄H₂₅ClN₆OS
Molecular Weight 481.01
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
InChi InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
InChi Key KIISCIGBPUVZBF-UHFFFAOYSA-N
PubChem CID 44607531
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

WZ-8040 is a potent EGFR inhibitor that suppresses the growth of EGFR-T790M (a mutation of the gatekeeper T790 residue) containing cell lines and inhibits EGFR phosphorylation.


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