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WZ-3146

A mutant selective EGFR inhibitor
Catalog #: B2206

In stock

SKU-Size Size Price Qty
B2206-1 1 mg
$85.00
B2206-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide
Appearance Crystalline solid
CAS # 1214265-56-1
Molecular Formula C₂₄H₂₅ClN₆O₂
Molecular Weight 464.95
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
InChi InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-2
InChi Key APHGZZPEOCCYNO-UHFFFAOYSA-N
PubChem CID 44607360
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

WZ-3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.


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