A potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor
Catalog #: B2219 | abID:

Product Details

Alternate Name (E)-8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide
Appearance Crystalline solid
CAS # 1206731-57-8
Molecular Formula C₂₇H₃₀N₄O₃
Molecular Weight 458.56
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C27H30N4O3/c32-26(15-9-1-2-10-16-27(33)30-34)29-28-21-22-17-19-25(20-18-22)31(23-11-5-3-6-12-23)24-13-7-4-8-14-24/h3-8,11-14,17-21,34H,1-2,9-10,15-16H2,(H,29,32)(H,30,33)/b28-21+
PubChem CID 44601455
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC₅₀ values ranging from 1.5 to 4.7 μM. WT161 enhances the cytotoxicity of bortezomib (Cat. No. 1846) and carfilzomib (Cat. No. 2385) against patient-derived multiple myeloma cells.

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