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WP1066

A JAK2 inhibitor
Catalog #: 1809
SKU-Size Size Price Qty
1809-5 5 mg
$100.00
1809-25 25 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Appearance Off-white solid
CAS # 857064-38-1
Molecular Formula C₁₇H₁₄BrN₃O
Molecular Weight 356.22
Purity ≥97% by HPLC
Solubility DMSO (10 mg/ml) and Ethanol (5 mg/ml)
SMILES CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
InChi InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChi Key VFUAJMPDXIRPKO-LQELWAHVSA-N
PubChem CID 11210478
MDL Number MFCD12912450
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.


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