Product Details
| abID | ab141440 |
|---|---|
| Alternate Name | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide |
| Appearance | Off-white solid |
| CAS # | 857064-38-1 |
| Molecular Formula | C₁₇H₁₄BrN₃O |
| Molecular Weight | 356.22 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO (10 mg/ml) and Ethanol (5 mg/ml) |
| SMILES | CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N |
| InChi | InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1 |
| InChi Key | VFUAJMPDXIRPKO-LQELWAHVSA-N |
| PubChem CID | 11210478 |
| MDL Number | MFCD12912450 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
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