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WP-1130

A selective DUB (deubiquitinases) inhibitor
Catalog #: 2014
SKU-Size Size Price Qty
2014-5 5 mg
$80.00
2014-25 25 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; Degrasyn
Appearance Pale yellow solid
CAS # 856243-80-6
Molecular Formula C₁₉H₁₈BrN₃O
Molecular Weight 384.27
Purity ≥98% by TLC
Solubility DMSO (40 mg/ml) or EtOH (25 mg/ml)
SMILES CCCC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
InChi InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
InChi Key LIDOPKHSVQTSJY-VMEIHUARSA-N
PubChem CID 11222830
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination.


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