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WNT-1, human recombinant

based on 2 citations in multiple journalsWNT-1, human recombinant24.1 4
A proto-oncogene implicated in oncogenesis and in several developmental processes
Catalog #: 4754
SKU-Size Size Price Qty
4754-10 10 μg
$205.00
4754-50 50 μg
$595.00
4754-1000 1 mg
$4,950.00
More Sizes Get Quote

Product Details

Alternate Name INT-1, Proto-oncogene Int-1 homolog
Gene Symbol WNT1
Gene ID 7471
Accession # P04628
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 38.4 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED₅₀ for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intraCellular signaling protein, β-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.


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Reuter et al., The Wnt/β-Catenin Pathway Attenuates Experimental Allergic Airway Disease. J. Immunol., Jul 2014; 193: 485 - 495.
Tawk, M. et. al. Wnt/β-Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis. J. Neurosci., Mar 2011; 31: 3729 - 3742.
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