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Wnt-1 Antibody

Catalog #: 5754
SKU-Size Size Price Qty
5754-30T 30 µg
$89.00
5754-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Wnt-1
Alternate Name Wnt-1 Polyclonal, Anti-Wnt-1 antibody, Wnt-1 antibody, Anti-Wnt-1, Wnt-1, Wnt, Wnt 1, Wnt1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli expressed human Wnt-1
Accession # P04628
Gene ID 7471
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 30 µg (0.5 mg/ml) affinity purified rabbit anti-human Wnt-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human Wnt-1 (Cat.# 4754-10) can be used as a positive control.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Wnt-1 is a secreted protein that signals throμgh the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues.


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