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Withaferin A

A steroidal lactone
Catalog #: B2716
SKU-Size Size Price Qty
B2716-1 1 mg
B2716-5 5 mg
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Product Details

Alternate Name NSC 101088, 5β,6β-epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oic acid, NSC 273757
Peptide Sequence N/A
Appearance White to off-white or slightly yellow crystalline solid
CAS # 5119-48-2
Molecular Formula C₂₈H₃₈O₆
Molecular Weight 470.60
Purity ≥98%
Solubility ~ 5 mg/ml DMSO
InChi InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
PubChem CID 265237
MDL Number MFCD10687098
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
USAGE For Research Use Only! Not For Use in Humans.


Withaferin A is a steroid lactone that displays potent anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.

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