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WIKI-4

A potent inhibitor of Wnt/β-catenin signaling
Catalog #: B1630
SKU-Size Size Price Qty
B1630-5 5 mg
$80.00
B1630-25 25 mg
$305.00
More Sizes Get Quote

Product Details

Alternate Name WIKI-4; WIKI 4; WIKI4; 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one
Appearance Solid
CAS # 838818-26-1
Molecular Formula C₂₉H₂₃N₅O₃S
Molecular Weight 521.59
Purity >98%
Solubility DMSO
SMILES COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6
InChi 1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3
InChi Key RNUXIZKXJOGYQP-UHFFFAOYSA-N
PubChem CID 2984337
MDL Number MFCD05885187
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).


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