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WAY-265497

An inhibitor of Cdk4
Catalog #: B2936
SKU-Size Size Price Qty
B2936-5 5 mg
$155.00
B2936-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name 4-[[[(4-Hydroxy-5-propoxy-2-pyridinyl)methyl]amino]methylene]-6-iodo-1,3(2H,4H)-isoquinolinedione; Cdk4 Inhibitor V
Appearance Solid
CAS # 943746-57-4
Molecular Formula C₁₉H₁₈IN₃O₄
Molecular Weight 479.27
Purity 95%
Solubility 50 mg/ml in DMSO
SMILES O=C1NC(/C(C2=C1C=CC(I)=C2)=C\NCC3=NC=C(OCCC)C(O)=C3)=O
InChi InChI=1S/C19H18IN3O4/c1-2-5-27-17-10-22-12(7-16(17)24)8-21-9-15-14-6-11(20)3-4-13(14)18(25)23-19(15)26/h3-4,6-7,9-10,21H,2,5,8H2,1H3,(H,22,24)(H,23,25,26)/b15-9-
InChi Key DXMZEMWEDCPBNA-DHDCSXOGSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM, respectively. It inhibits Cdk2/E and Cdk1/B at higher concentrations with IC₅₀ values of 1.6 µM and 25.3 µM, respectively.


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