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VX-809

A novel CFTR corrector
Catalog #: 2857
SKU-Size Size Price Qty
2857-5 5 mg
$125.00
2857-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid; Lumacaftor
Appearance White to off-white solid
CAS # 936727-05-8
Molecular Formula C₂₄H₁₈F₂N₂O₅
Molecular Weight 452.41
Purity ≥98% by HPLC
Solubility DMSO (>90 mg/ml)
SMILES CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
InChi InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChi Key UFSKUSARDNFIRC-UHFFFAOYSA-N
PubChem CID 16678941
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.


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