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VX-765

A selective caspase-1 inhibitor
Catalog #: 2781
SKU-Size Size Price Qty
2781-5 5 mg
$115.00
2781-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide; Belnacasan
Appearance White to off-white solid
CAS # 273404-37-8
Molecular Formula C₂₄H₃₃ClN₄O₆
Molecular Weight 508.99
Purity ≥98% by HPLC
Solubility DMSO (~ 200 mg/ml)
SMILES CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
InChi InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1
InChi Key SJDDOCKBXFJEJB-MOKWFATOSA-N
PubChem CID 11398092
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against caspase-3 and -6 to -9. Exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18.


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