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A potent and selective inhibitor of p38α
Catalog #: 2812
SKU-Size Size Price Qty
2812-5 5 mg
2812-25 25 mg
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Product Details

Alternate Name 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one
Appearance Yellow solid
CAS # 209410-46-8
Molecular Formula C₁₉H₉Cl₂F₂N₃OS
Molecular Weight 436.26
Purity ≥98% by HPLC
Solubility DMSO (~40 mg/ml)
SMILES C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
InChi InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
PubChem CID 3038525
MDL Number MFCD09834070
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


VX-745 is a potent and selective inhibitor of p38α (IC₅₀ = 10 nM). It displays 22-fold greater selectivity versus p38β and no inhibition of p38γ. Also blocks TNFα production in LPS-stimulated HWB in vitro (IC₅₀ = 177 nM).

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