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Product Details
| Alternate Name | 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one |
|---|---|
| Appearance | Yellow solid |
| CAS # | 209410-46-8 |
| Molecular Formula | C₁₉H₉Cl₂F₂N₃OS |
| Molecular Weight | 436.26 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~40 mg/ml) |
| SMILES | C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl |
| InChi | InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H |
| InChi Key | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
| PubChem CID | 3038525 |
| MDL Number | MFCD09834070 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
VX-745 is a potent and selective inhibitor of p38α (IC₅₀ = 10 nM). It displays 22-fold greater selectivity versus p38β and no inhibition of p38γ. Also blocks TNFα production in LPS-stimulated HWB in vitro (IC₅₀ = 177 nM).
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