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VX-702

A p38 MAP kinase inhibitor
Catalog #: 1598
SKU-Size Size Price Qty
1598-1 1 mg
$310.00
1598-5 5 mg
$940.00
More Sizes Get Quote

Product Details

Alternate Name 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Appearance White soild
CAS # 745833-23-2
Molecular Formula C₁₉H₁₂F₄N₄O₂
Molecular Weight 404.32
Purity ≥99% by HPLC
Solubility DMSO
SMILES C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
InChi InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChi Key FYSRKRZDBHOFAY-UHFFFAOYSA-N
PubChem CID 10341154
MDL Number MFCD11616590
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1β and TNFα (IC₅₀ = 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 µM) completely or partially inhibited platelet agonist induced p38 activation (IC₅₀= 4 to 20 nM).


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